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Profile

Dr. Delroy M. Louden Ph. D., FRSH Principal Investigator

Professor Delroy M Louden has held academic appointments at universities in Nigeria, The West Indies, Canada, and the United States. His distinguished awards include:

1996            Fellow of the Royal Society of Health (UK)

1995            United States Public Health Service - Bureau of Primary
                    Health Care Policy Fellowship

1985-1987   Distinguished Fulbright Scholar National Institute of Mental
                   Health Epidemiology and Biostatistics Division - Maryland

1986-1988   Post-Doctoral Fellowship The Johns Hopkins University
                   School of Public Health

Dr. Louden has training in epidemiology, psychology and public health, over thirty years' executive and international experience in academic settings and the non- profit community. He has worked in Nigeria, the Caribbean, Europe, and North America. His non-profit experience includes - Director of Epidemiology and Surveillance, New York City,Department of Health, Bureau of Tuberculosis; Vice President for Research and, later, Executive Director-Center for Research in Nursing Education and Community Heath at the National League for Nursing in New York were he developed a Memorandum of Understanding on Nursing Education Research with the Spanish Nursing Association, and also with Madigol University in Thailand.

His international experience includes conducting a KAP (Knowledge Attitudes and Practices) survey, and conducting Peer Health Educator Training regarding HIV/AIDS with the Armed Forces Program on AIDS Control (AFPAC) in Nigeria; Lead Investigator for the Harambee Foundation in Toronto, Canada (a community-based prevalence and incidence study on drug abuse in metropolitan Toronto); The Organization of American States (family planning attitudes in adolescents parents in the English-speaking Caribbean); served as a member of the Government of Jamaica Task Force on Work Attitudes; and Vice-Chairperson of the Medical Committee and the Clinical Records Quality Assurance Committee at the University Hospital of the West Indies, Jamaica.

While at the University of the West Indies Mona (1980-85), Dr. Louden was involved with the faculty of Medicine in the preparation of several papers to the Caribbean Ministers of Health, notably the mental health needs of smaller Caribbean states. In addition as a UWI faculty member he was involved in the Kellogg Foundation Establishment of the Primary Care Center in St. Lucia as well as coordinating UWI - Mona activities in the development of Mount Hope Medical Complex in Trinidad. A former Fulbright Scholar, he has held academic appointments at universities in England, Canada, Nigeria, and in the USA.

He has provided consultation in a variety of settings, more recently with the US government federal agency, Substance Abuse and Mental Health Administration (SAMHSA); Associate Administrator for HIV/AIDS, Project Integration of HIV/AIDS Substance Abuse, Mental Health, and Hepatitis; as Track Co-chair at CDC 2002 National HIV Prevention Conference; monitoring and evaluation including conducting site visits; the development of chart review instruments for primary medical care, case management, and client satisfaction surveys of CBOs providing services to HIV/AIDS clients in Washington DC and the surrounding metropolitan areas; Grant reviewer for SAMHSA and HRSA, on SPNS (special projects of national significance), early intervention services and the Office of Minority Health - DHSS Bilingual/ Bicultural Service Demonstration Program; the Community Health Accreditation Program (CHAP) Project - Benchmark for Excellence in Home Care; and the National Institute for Drug Abuse Special Population Research Training Seminar.

Dr. Louden is a member of the American College of Epidemiology, American Public Health Association and the Society for Epidemiological Research.


Karen A. Baskerville, Ph.D.

Education/Training

Northwestern University, Evanston, IL
University of Memphis, Memphis, TN B.A.
N/A 1990 1989 Chemistry
The University of Tennessee, Memphis, Memphis, TN Mayo Clinic, Jacksonville, FL Ph.D.
Postdoctoral 1996 1999-2006 Anatomy & Neurobiology Neuroscience
Grant Writing Workshop
Society for Neuroscience, New Orleans, LA Workshop
Short Course 1999
2000 Grant preparation
DNA Microarrays
Society for Neuroscience, San Diego, CA Short Course 2001 Cell Death
Microarray Workshop, University of Florida, Gainesville, FL
GeneSpring (Silicon Genetics), Research Triangle, NC
Statistical Learning, Georgetown Univ., Washington, D.C. Workshop
Workshop
Short Course 2003
2004
2004 Microarrays; Real-time PCR
Microarray Analysis
Statistics

A. Positions and Honors

Research Experience
2007 (summer) Visiting Professor, Broad Institute of MIT and Harvard, Cambridge, MA
Mentor: Dr. Li-Huei Tsai, Picower Institute of MIT
Research Project: Oxidative damage markers in p25, Alzheimer disease mouse model
1999-2006 Senior Research Fellow, Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL
Mentor: Dr. Michael McKinney
Research Projects: Gene expression of cholinergic neurons and brain microvessels in aging; gene expression of brain and peripheral lymphomas; cholinergic neuronal cell counts in behaviorally characterized rats
Additional duties: Train and mentor high school, undergraduate, and graduate students in research
1998 (summer) Mayo Minority Scholars Program Faculty Fellow, Department of Pharmacology, Mayo Clinic, Jacksonville, FL
1991 (summer) American Psychological Association Minority Fellowship Program in Neuroscience Fellow in a neuroscience summer enrichment program at the Marine Biological Laboratory, Woods Hole, MA
1990 1996 Graduate Student, Department of Anatomy and Neurobiology, The University of Tennessee, Memphis,
Memphis, TN; Dissertation: Acetylcholine in the Somatosensory Cortex of the Rat
Graduate advisor and mentor: Dr. Paul Herron; Chair of dissertation committee: Dr. Robert Foehring
Additional duties: Train and mentor high school, undergraduate, and medical students in research
1990 (summer) Summer Research Student, Tennessee Preprofessional Program, Department of Anatomy and Neurobiology,
The University of Tennessee, Memphis, Memphis, TN

Teaching Experience
2007-present Adjunct Professor, South University Online, course: medical terminology
2006-present Assistant Professor of Biology, Department of Biology, School of Natural Sciences and Mathematics, Lincoln University, Lincoln University, PA
1997 (summer) Volunteer Research Course Teacher, Summer Science Camp for 7th-9th grade students, The University of Tennessee, Memphis, Memphis, TN
1996 1999 Assistant Professor of Biology, Division of Science and Mathematics, Rust College, Holly Springs, MS
Courses taught: histology, anatomy and physiology, molecular biology, genetics, microbiology, nutrition, and
comparative vertebrate anatomy
Students taught: biology majors, other science majors, and pre-health students
1992 (Dec) 1994 Volunteer Science Laboratory Teacher for 4th – 6th graders, Gordon Elementary School, Memphis, TN
1992-1995 Teaching Assistant, Department of Anatomy and Neurobiology, The University of Tennessee, Memphis, TN
Courses taught: gross anatomy and histology
Students taught: medical, dental, pharmacy, physical therapy, and occupational therapy students
1991 1993 Learning Specialist, Shelby State Upward Bound Program, Shelby State Community College, Memphis, TN
Courses taught and/or tutored: chemistry, biology, calculus, and algebra
1991 (March) Guest Lecturer, Medical Ethics Class, University of Memphis, Memphis, TN
1990 (spring) Teacher Assistant, Memphis City Schools, Dunn Avenue Elementary School, Memphis, TN

Administrative Experience
1999 (summer) Acting chair, Division of Science and Mathematics, Rust College, Holly Springs, MS
1996-1999 NIGMS Minority Biomedical Research Support Program Investigator and Mentor, Rust College, Holly Springs, MS
Supervised research assistant and undergraduate students in research
1996-1998 Minority Access to Research Careers Mentor, Rust College, Holly Springs, MS
1996-1998 Alliance for Minority Participation Coordinator, Rust College, Holly Springs, MS
1996-1999 Academic Advisor for biology majors and Pre-health Advisor, Rust College, Holly Springs, MS
1991 1995 Graduate School Representative of Black Student Advisory Council and Memphis McNair Advisory Board, The University of Tennessee, Memphis, Memphis, TN
1988-1989 President, One Step Before (OSB) African American Pre-health Society, Northwestern University, Evanston, IL; also served as secretary (1986-1987) and vice-president (1987-1988)

Seminars and Workshops
2007 Leadership Development Conference for STEM Women, Columbia, MD
2007 Quality Education for Minorities (QEM) Network/NSF BIO Workshop, New Orleans, LA
2007 Math Science Partnership of Greater Philadelphia Participant
2006 Panelist, Teaching Urban Youth Mathematics and Science, St. Joseph’s University, Philadelphia, PA
2005 Research Seminar, Co-presenter, Mayo Clinic, Jacksonville, FL
1996 (August) Volunteer Brain Demonstrator, “It’s All in Your Head” Exhibit, Pink Palace Museum, Memphis, TN
1993-1995 Held Workshop in spring, entitled, Get Fit with Anatomy, for Expanding Your Horizons in Science and Mathematics Conference for girls in 5th – 8th grades, The University of Tennessee, Memphis, Memphis, TN
1993 Student Research Seminar, Center for Neuroscience, The University of Tennessee, Memphis, Memphis, TN

Other Experience
2006, 2007 Science Fair Judge, Lincoln University, Lincoln University, PA
2006 Career Fair Participant, Lee High School, Jacksonville, FL
2003 Panel Participant, Minority Health Careers Symposium, University of North Florida, Jacksonville, FL
1997-1999 Environmental Justice Program Participant, Rust College, Holly Springs, MS
1988 (summer) Volunteer in emergency room, LeBonheur Children’s Medical Center, Memphis, TN
1987 (summer) Pediatric Medical Assistant, Ethelyn Williams Neal, M.D., Comprehensive Medical Associates, Memphis, TN
1987-1989 Assistant to Supervisor, Seeley G. Mudd Science Engineering Library, Northwestern University, Evanston, IL
1985 1986 Student Assistant, Seeley G. Mudd Science Engineering Library, Northwestern University, Evanston, IL

Honors, Awards, and Memberships
2007 Faculty Host for Dr. Benjamin Carson, Lincoln University Commencement
2006 Travel Award, Professional Development Workshop for Junior Faculty and Postdoctoral Fellows, American Society for Cell Biology, Woods Hole, MA (June 22-23, 2006)
2000 International Who’s Who of Professionals
1998-1999 UNCF HIV/AIDS Orientation and Professional Education (HOPE) Program Grant, Principal Investigator
1998 Higher Education Appreciation Day - Working for Academic Excellence (HEADWAE) Faculty Honoree, The Mississippi Legislature
1997 Exemplary Teacher Award, United Methodist Church
1996 IMHOTEP Leadership Society, The University of Tennessee, Memphis
1995 Academic Excellence and Service Award, University Relations, The University of Tennessee, Memphis
1995 Academic All American College Scholar
1993 Society for Neuroscience/NINDS Minority Travel Fellowship Award
1992 Young Scientist Award, Berkshire Neuroscience Symposium, Conte Institute for Environmental Health, Jiminy
Peak, MA
1991-1994 American Psychological Association Minority Fellowship in Neuroscience
1988-1990 Tennessee Preprofessional Program, The University of Tennessee, Memphis
1987 Outstanding College Students of America
1986 Alpha Lambda Delta (National Freshman Honor Society)
1985-1989 Academic and Service Awards, One Step Before (OSB) African American Pre-health Society, Northwestern University, Evanston, IL
1985 Dean's List, Northwestern University
1999-2004 American Association for the Advancement of Science
1992-present Society for Neuroscience
2007-present Beta Beta Beta National Biological Honor Society

B. Selected peer-reviewed publications (in chronological order)

Publications
Johnson, E. F., McClure, J., Herron, P., and Baskerville, K. A. (1993) Anatomical variation, human diversity, and environmental
adaptation. J. Natl. Med. Assoc. 85:337 338.
Baskerville, K.A., Chang, H.T., and Herron, P. (1993) Topography of cholinergic afferents from the nucleus basalis of Meynert to
representational areas of sensorimotor cortices in the rat. J. Comp. Neurol. 335:552 562.
Herron, P., Baskerville, K.A., Chang, H.T., and Doetsch, G.S. (1997) Distribution of neurons immunoreactive for parvalbumin and
calbindin in the somatosensory thalamus of the raccoon. J. Comp. Neurol. 388:120-129.
Baskerville, K.A., Schweitzer, J.B., and Herron, P. (1997) Effects of cholinergic depletion on experience-dependent plasticity in the
cortex of the rat. Neurosci. 80:1159-1169.
Nicolle, M.M., Gonzalez, J., Sugaya, K., Baskerville, K.A., Bryan, D., Lund, K., Gallagher, M., and McKinney, M. (2001)
Signatures of hippocampal oxidative stress in aged spatial learning-impaired rodents. Neurosci. 107:415-431.
McKinney, M., Williams, K., Personett, D., Kent, C., Bryan, D., Gonzalez, J., and Baskerville, K. (2004) Pontine cholinergic neurons
depend on three neuroprotective systems to resist nitrosative stress. Brain Res. 1002:100-109.
Baskerville, K.A., Kent, C., Nicolle, M.M., Gallagher, M., and McKinney, M. (2006) Aging causes partial loss of basal forebrain
but no loss of pontine reticular cholinergic neurons. NeuroReport. 17:1819-1823.
Personett D.A., Williams K., Baskerville K.A., McKinney M. (2007) Establishment of cholinergic neuron-like cell lines with
differential vulnerability to nitrosative stress. Curr Neurovasc Res. 4:75-88.
Baskerville, K.A., Kent, C., Personett, D., Lai, W., Park, P., Coleman, P., and McKinney, M. (2007) Aging elevates metabolic gene
expression in brain cholinergic neurons. Neurobiology of Aging. In press.
Tun, H.W., Personett, D., Baskerville, K.A., Menke, D.M., Jaeckle, K.A., Kreinest, P., Edenfield, B., Zubair, A.C., O'Neill, B.P., Lai,
W.R., Park, P.J., and McKinney, M. (2008) Pathway analysis of primary central nervous system lymphoma. Blood. In press.

Book Chapters
McKinney, M., Baskerville, K., Personett, D., Williams, K., and Gonzales, J. (2003) Cholinergic plasticity and the meaning of death.
In Neuronal and Vascular Plasticity: Elucidating Basic Cellular Mechanisms for Future Therapeutic Discovery. (ed. K. Maiese)
Kluwer Academic Publishers, Norwell, MA.

Abstracts
Baskerville, K. A., Herron, P., and Chang, H.T. (1991) The organization of cholinergic projections from the nucleus basalis of
Meynert to sensory motor cortices. Soc. Neurosci. Abstr. 17:624.
Baskerville, K.A., Herron, P., and Chang, H.T. (1992) The organization of corticocortical and callosal projection neurons and
calbindin immunoreactive neurons in the rat second somatosensory cortex. Soc. Neurosci. Abstr. 18:1387.
Baskerville, K.A., Herron, P., and Chang, H.T. (1993) Relationship of calbindin with corticocortical projection neurons in the rat
second somatosensory cortex. Soc. Neurosci. Abstr. 19:1567.
Baskerville, K.A., Johnson, E.F., Geller, A.M., and McClure, J.F. (1994) Improving elementary science laboratories in the Memphis
City Schools.
Herron, P., Schweitzer, J.B., Baskerville, K.A., Book, A.A., and Wiley, R.G. (1994) Responsiveness of the somatosensory cortex
following the selective lesioning of cholinergic neurons in nucleus basalis of Meynert. Soc. Neurosci. Abstr. 20:755.
Baskerville, K. A., Heaston, N.R., Schweitzer, J. B., and Herron, P. (1995) Role of acetylcholine in experience dependent plasticity
in the somatosensory cortex of the rat. Soc. Neurosci. Abstr. 21:123.
Baskerville, K.A., Bryan, D., Gallagher, M., and McKinney, M. (2000) NF-?B activation in aged Long-Evans rats. Soc. Neurosci.
Abstr. 26:1047.
Personett, D.A., Williams, K., Baskerville, K., and McKinney, M. (2002) Neuroprotection systems in cholinergic neuron-like cells.
Soc. Neurosci. Abstr. 28.
Baskerville, K., Williams, K., and McKinney, M. (2002) Microarray analysis of laser-microdissected cholinergic neurons. Soc.
Neurosci. Abstr. 28.
Baskerville, K. A., Williams, K., and McKinney, M. (2003) Microarray Analysis of Brain Microvessels in Young and Aged Fischer
344 Rats. Soc. Neurosci. Abstr. 29.


C. Research Support

Ongoing Research Support
Christian R. and Mary F. Lindback Foundation of Philadelphia Minority Junior Faculty Award 2007-2008
Vulnerability of Cholinergic Neurons in Alzheimer's Disease
Role: PI

Office of Research Development, Planning and Coordination at Lincoln University Mini-Grant 2007-2008
Effects of Antioxidants on the Aging Brain Microvasculature
Role: PI

Pennsylvania Department of Health, Colorectal Cancer Grant in partnership with Pennsylvania State College of Medicine, Lehigh Valley Hospital and Northeast Regional Cancer Institute 2007 – 2011
PI at Lincoln: Dr. Delroy Louden
Role: Faculty participant

Completed Research Support
1R03AG012795-01 Baskerville (PI) 9/1/94-12/31/95
NIA
Ach and Cortical Plasticity in the Aging Brain
Role: PI

5514GM002866-140006 Baskerville (PI) 1999
NIGMS
Connections and Metabolic Activities of the Second Somatosensory Cortex
Role: PI

Grant-In-Aid McKinney (PI) 7/1/03-06/30/06
American Heart Association
“Molecular Bases of Age-related Stroke Susceptibility”
Role: Postdoctoral fellow

P01AG09973 Gallagher (PI); McKinney (Project 05) 9/1/90-11/30/06
NIA
Mechanisms of Hippocampal Dysfunction in Aging
Role: Postdoctoral Fellow/Minority Supplement (McKinney Project 05; 8/16/99-8/15/00)
Role: Postdoctoral Fellow (McKinney Project 05; 8/16/00-present)

Tun (PI) 10/1/04-10/30/06
Mayo Clinic CR-10
DNA Microarray Comparison Between Newly-Diagnosed Primary CNS and Peripheral Diffuse Large Cell Lymphomas:
A Pilot Study
Role: Co-investigator